Expression of glial fibrillary acidic protein (GFAP) in goldfish optic nerve following injury
作者:
C. A. Stafford,
S. A. S. Shehab,
S. N. Nona,
J. R. Cronly‐Dillon,
期刊:
Glia
(WILEY Available online 1990)
卷期:
Volume 3,
issue 1
页码: 33-42
ISSN:0894-1491
年代: 1990
DOI:10.1002/glia.440030106
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Regeneration;Reactive astrocytes;Immunoblotting;Immunohistochemistry
数据来源: WILEY
摘要:
AbstractBy using an antibody to goldfish glial fibrillary acidic protein (GFAP), the reaction of goldfish optic nerve to injury has been studied by immunoblotting and immunohistochemical methods. Goldfish optic nerve, which normally lacks GFAP immunoreactivity (Nona et al.:Glia, 2:189–200, 1989), expresses GFAP following injury. This immunoreactivity, which is observed as early as 10 days after crush and which is still evident at 30 days after crush, all but disappears by 150 days after crush. Since it is well established that functional restoration of synaptic connections and the recovery of vision takes place in goldfish following optic nerve injury, our results indicate that reactive astrocytes do not represent an impediment to regeneration in goldfish visual syste
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