Histologic grade has been shown repeatedly to be the most important prognostic factor in adult soft tissue sarcomas with regard to metastasis development and tumor morrality, although tumor size and tumor location (superficial versus deep) are also important parameters to consider. In this review, the advantages and limitations of histrologic grade are exposed, focusing on the grading system of the Fédération Nationale des Centres de Lutte Contre fe Cancer. The reproducibility issue and the impact of histologic grade on patient management are also discussed.