Intrahepatic Cholestasis Induced by Amoxicillin/Clavulanic Acid (Augmentin®): A Report on Two Cases
作者:
AlexanderP.,
RoskamsT.,
SteenbergenW. Van,
PeetennansW.,
DesmetV.,
YapS.H.,
期刊:
Acta Clinica Belgica
(Taylor Available online 1991)
卷期:
Volume 46,
issue 5
页码: 327-332
ISSN:1784-3286
年代: 1991
DOI:10.1080/17843286.1991.11718184
出版商: Taylor&Francis
数据来源: Taylor
摘要:
SummaryTwo patients who developed a severe but; reversible cholestatic jaundice during and after treatment with an amoxicillin/clavulanic acid Preparation (Augmentin®) are described. The diagnosis of drug-induced intrahepatic cholestasis was based on the clinical course, biochemical pattern and on histological findings. Since amoxicillin alone does not induce liver injury, the combination of amoxicillin and clavulanic acid or clavulanic acid alone could be responsible for this adverse reaction, Probably through a metabolic idiosyncrasy or a hypersensitivity mechanism. Although more than 1 OOcases of hepatotoxic reactions have been reported to the pharmaceutical company (Beecham Laboratories) and several reports have been Published, the incidence of hepatotoxicity of this antibiotic is relatively rare, since this antibiotic has been widely used. However, recognition of this benign and reversible cholestatic syndrome is important to avoid unnecessary, expensive and invasive diagnostic procedures.
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