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Short or continuous social stress: suppression of continuously available ethanol intake in subordinate rats

 

作者: A.M.M. van Erp,   N. Tachi,   K.A. Miczek,  

 

期刊: Behavioural Pharmacology  (OVID Available online 2001)
卷期: Volume 12, issue 5  

页码: 335-342

 

ISSN:0955-8810

 

年代: 2001

 

出版商: OVID

 

关键词: alcohol;social stress;withdrawal;tactile startle;chronic stress;intermittent stress;acute stress

 

数据来源: OVID

 

摘要:

We explored the effects of short, intermediate, and continuous social stress on daily ethanol and water intake in rats. The study was designed to: (1) detect increases in intake during hours when animals were not stressed; and (2) detect shifts in preference from solutions with high to low alcohol content. Male Long–Evans rats acquired ethanol self‐administration using a sucrose‐fading procedure, which was followed by continuous access to 10% and 3% ethanol solutions and water. After intake stabilized, rats were exposed to three periods of five consecutive days of social stress, with 8–10 days without stress in between. Short social stress consisted of being attacked and defeated by an aggressive opponent, followed by 30 min exposure to threats by the aggressive male while in a protective cage. Intermediate and continuous social stress consisted of a 6 h or 24 h ‘threat of attack’ exposure, respectively. All stress exposures reduced daily intake of 10% ethanol, did not cause changes in intake of 3% ethanol, and caused increases in water intake. No compensatory ethanol consumption was observed on stress days or after stress exposure was discontinued. These results are at variance with the hypothesis for increased alcohol consumption during or following social stress episodes.

 

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