Temporary Change of Compound Action Potential Amplitude after Intense Sound Exposure
作者:
Tomoo Homma,
Makoto Hasegawa,
Ayari Okamoto,
Kazunori Yokoyama,
Toshiyo Tamura,
期刊:
ORL
(Karger Available online 1994)
卷期:
Volume 56,
issue 1
页码: 19-23
ISSN:0301-1569
年代: 1994
DOI:10.1159/000276602
出版商: S. Karger AG
关键词: Compound action potential amplitude;Temporary threshold shift;Hair cell;Guinea pig
数据来源: Karger
摘要:
Intense sound induces a temporary or permanent threshold shift. The aim of this study is to make an experimental model for temporary threshold shift (TTS) using guinea pigs. In this study, two kinds of sound exposure were used for inducing a threshold shift in the guinea pig; one of 110 dB SPL at 10 kHz for 10 min and the other of 120 dB SPL at 10 kHz for 5 min. The former condition produced different levels of reduction in compound action potential (CAP) immediately after sound exposure and different steady levels of CAP amplitude after recovery (within 120 min) in 10 guinea pigs. The latter condition produced a total loss of CAP amplitude immediately after sound exposure in 8 of 9 guinea pigs, and this condition continued for 120 min in 7 of the 9 guinea pigs. Additionally, in 2 of 3 guinea pigs which were exposed the sound of 120 dB SPL at 10 kHz for 5 min, the CAP amplitudes were almost the same as those of control animals 1 day after the exposure. One the basis of these results, we consider the sound of 120 dB SPL at 10 kHz for 5 min to be the optimal intensity and frequency of sound and duration of exposure for producing a TTS in the guinea pig.
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