The in vivo role of stem cell factor (c‐kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice
作者:
R. K. GRENCIS,
K. J. ELSE,
J. F. HUNTLEY,
S. I. NISHIKAWA,
期刊:
Parasite Immunology
(WILEY Available online 1993)
卷期:
Volume 15,
issue 1
页码: 55-59
ISSN:0141-9838
年代: 1993
DOI:10.1111/j.1365-3024.1993.tb00572.x
出版商: Blackwell Publishing Ltd
关键词: Stem cell factor;c‐kit;T. spiralis;mast cells;mast cell protease
数据来源: WILEY
摘要:
SUMMARYThe role of stem cell factor (SCF) in the generation of intestinal mast cell hyperplasia and host protective immunity following helminth infection was investigated using the Trichinella spiralis/mouse model. In vivo administration of a monoclonal antibody specific for the receptor for SCF (c‐kit) was found to completely prevent the generation of intestinal mastocytosis normally observed following T. spiralis infection. This was reflected by markedly reduced intestinal mast cell protease (IMCP) levels in both tissue and serum. Moreover, animals treated with anti‐c‐kit antibody failed to show any evidence of worm expulsion from the gut. The data demonstrate for the first time, a critical role for the SCF in the generation of mucosal mastocytosis and host protective immunity following an intestinal helminth infe
点击下载:
PDF
(476KB)
返 回