AbstractA computer program for high‐speed simulation and optimization of electrophoretic processes has been developed for carrier‐free systems of all kinds. The calculations are based on the one‐dimensional dynamic (transient‐state) model. The three‐dimensional geometry of the simulation space can be chosen deliberately. With a highly efficient transport algorithm instead of complicated integration schemes for the transport equations, the calculation time can be effectively spent on various important parameters such as ionic strength, temperature, Joule heat, activity coefficients and concentration changes due to membranes. The parameter set of any carrier free electrophoretic method (i.e., continuous‐flow electrophoresis, capillary isotachophoresis and high performance capillary zone electrophoresis) can be imported directly into the computer program by means of a graphic user interface. The program performs overnight‐simulation of any electrophoretic system containing up to