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A short and general synthesis of 1,3‐dihydro‐6‐heteroaryl‐5‐perfluoroalkyl‐2H‐imidazo[4,5‐b]pyridin‐2‐ones

 

作者: Gee‐Hong Kuo,   Edward R. Bacon,   Baldev Singh,   Michael A. Eissenstat,   George Y. Lesher,  

 

期刊: Journal of Heterocyclic Chemistry  （WILEY Available online 1993）
卷期: Volume 30, issue 1  

页码: 37-40

 

ISSN:0022-152X

 

年代: 1993

 

DOI:10.1002/jhet.5570300107

 

出版商: Wiley‐Blackwell

 

数据来源: WILEY

 

摘要:

AbstractTrifluoro or pentafluoroacylation of heteroaryl‐enamines2a,bgave the corresponding perfluoroacylated heteroaryl‐enamines3a‐c. Heating the latter compounds with diethyl iminomalonate gave 2‐amino‐3‐pyridinecarboxylates4a‐c. Hydrolysis to the free acids5a‐c, and reaction with diphenylphosphoryl azide afforded the desired 1,3‐dihydro‐6‐heteroaryl‐5‐perfluoroalkyl‐2H‐imi

 

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