ADMINISTRATION OF OKT3 AS A TWO-HOUR INFUSION ATTENUATES FIRST-DOSE SIDE EFFECTS1
作者:
Buysmann2,3 Saskia,
Hack4 C.,
van Diepen3 Frank,
Surachno2 Janto,
ten Berge2,3,5 Ineke,
期刊:
Transplantation
(OVID Available online 1997)
卷期:
Volume 64,
issue 11
页码: 1620-1623
ISSN:0041-1337
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
Background.Use of the murine CD3 monoclonal antibody OKT3 is limited by first-dose side effects, which are thought to be caused by the release of inflammatory mediators. Because these processes might be influenced by the speed of administration, we compared a 2-hr OKT3 infusion with the bolus infusion usually applied nowadays.Methods.Eighteen renal allograft recipients were prophylactically treated with OKT3 and randomized to receive the first dose either as a 2-hr infusion or as an intravenous bolus infusion. Clinical side effects score and the occurrence of complement activation, cytokine release, and activation of neutrophils were determined.Results.Two-hour infusion of OKT3 completely prevented the occurrence of dyspnea, reduced the incidence of other side effects, and attenuated complement activation. Cytokine release and depletion of peripheral blood lymphocytes were similar in both groups.Conclusions.Thus, complement activation seems to play an additional role in the development of side effects after the first OKT3 dose.
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