AbstractThe cellular slime moldDictyostelium discoideumis becoming the premier system for the explication of the biochemical and cellular events that occur during motile processes. Proteins associated with the actin cytoskeleton, in particular, appear to play key roles in cellular responses to many external stimuli. This review summarizes our present understanding of the actin‐associated proteins inDictyostelium, including their in vitro activities and their structural and/or functional analogues in mammalian cell