The Role of Epstein-Barr Virus Subtypes in Human Immunodeficiency Virus-Associated Lymphoma
作者:
BoyleM. J.,
SculleyT. B.,
PennyR.,
SewellW. A.,
TschuchniggM.,
BergerM. F.,
CooperD. A.,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 10,
issue 1-2
页码: 17-23
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309147352
出版商: Taylor&Francis
关键词: HIV-associated lymphoma;EBV;EBV subtypes human immunodeficiency virus
数据来源: Taylor
摘要:
High grade B cell non-Hodgkin's lymphoma (NHL) is an increasingly important problem in individuals infected with the human immunodeficiency virus (HIV). Fifty percent of these tumours harbour the Epstein-Barr virus (EBV) and there is an equal frequency of EBV A and B-subtypes in the tumours. This contrasts with the recent report that only A-type EBV is associated with Hodgkin's disease. Such studies are challenging the traditional models of EBV-associated lymphomagenesis and showing the way for further studies in this field. This article reviews the studies of EBV subtypes in HIV-associated NHL and uses this new knowledge to discuss the role of EBV in lymphomagenesis.
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