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INHIBITION OF DNA REPAIR AND PRODUCTION OF SINGLE‐STRAND BREAKS INESCHERICHIA COLIBY REDUCTONE

 

作者: A. C. Leitão,   L. R. Caldas,   R. Alcantara Gomes,  

 

期刊: Photochemistry and Photobiology  （WILEY Available online 1981）
卷期: Volume 33, issue 1  

页码: 49-53

 

ISSN:0031-8655

 

年代: 1981

 

DOI:10.1111/j.1751-1097.1981.tb04295.x

 

出版商: Blackwell Publishing Ltd

 

数据来源: WILEY

 

摘要:

Abstract—Reductone (HOCH2COCHO), a keto‐aldehyde produced by thermal degradation of some sugars, at alkaline pHs, blocks the excision repair of DNA lesions in uv‐irradiated wild typeEscherichia coli.This probably occurs as a result of inhibition of the exonucleolytic activity of DNA polymerase I. In addition, reductone alone induces DNA single‐strand breaks. Repair of this damage is mainly dependent on thepolAgene p

 

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