Continuous positive airway pressure improves nocturnal baroreflex sensitivity of patients with heart failure and obstructive sleep apnea
作者:
Ruzena Tkacova,
Hilmi Dajani,
Fiona Rankin,
Fabia Fitzgerald,
John Floras,
T Bradley,
期刊:
Journal of Hypertension
(OVID Available online 2000)
卷期:
Volume 18,
issue 9
页码: 1257-1262
ISSN:0263-6352
年代: 2000
出版商: OVID
关键词: cardiovascular autonomic control;reflex control of heart rate;reflex control of blood pressure
数据来源: OVID
摘要:
ObjectivesTo determine the acute effects of continuous positive airway pressure (CPAP) on baroreceptor reflex sensitivity (BRS) for heart rate during sleep in congestive heart failure (CHF) patients with obstructive sleep apnea (OSA).Design and methodsIn eight CHF patients with OSA not previously treated with CPAP, spontaneous BRS was assessed during overnight polysomnography prior to the onset of sleep, and during stage 2 non-rapid eye movement sleep (NREM) before, during and after application of CPAP.ResultsCPAP alleviated OSA and acutely increased the slope of BRS (median, 25%,75%) [from 3.9 (3.5, 4.8) to 6.2 (4.6, 26.2) ms/mmHg,P< 0.05]. Increases in the slope of BRS persisted following withdrawal of CPAP [4.9 (4.3, 6.9) ms/mmHg,P< 0.05]. CPAP also lowered heart rate (from 81.3 ± 4.9 to 76.0 ± 5.7 bpm,P< 0.05), an effect which persisted after its withdrawal (76.7 ± 5.7 bpm,P< 0.05). Systolic blood pressure at the midpoint of the pressure range of BRS sequences fell while on CPAP (from 139 ± 8 to 120 ± 7 mmHg,P< 0.05), and remained lower following CPAP withdrawal (124 ± 9 mmHg,P< 0.05).ConclusionsIn CHF patients with OSA, CPAP increases acutely BRS during sleep, lowers heart rate and resets the operating point for BRS to a lower blood pressure. These effects of CPAP persist after its withdrawal, suggesting that nocturnal CPAP therapy may cause sustained improvement in the neural control of heart rate.
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