Human Exposure to 2,3,7,8-TCDD and Risk of Cancer
作者:
JohnsonEric S.,
期刊:
Critical Reviews in Toxicology
(Taylor Available online 1992)
卷期:
Volume 21,
issue 6
页码: 451-463
ISSN:1040-8444
年代: 1992
DOI:10.3109/10408449209089883
出版商: Taylor&Francis
关键词: 2,3,7,8-tetrachlorodibenzo-p-dioxin;TCDD;phenoxyacetic acids;chlorophenols;soft-tissue sarcoma;malignant lymphoma;cancer
数据来源: Taylor
摘要:
AbstractMost of the evidence for the carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in humans has centered around whether it causes malignant lymphomas (ML) and soft-tissue sarcomas (STS). A critical review of the literature indicates that the evidence does not support a causal role for TCDD in the etiology of ML. For STS, the evidence does not specifically incriminate TCDD either, although there is room for doubt. Cancers of other sites, particularly of the respiratory system and thyroid which were found to be statistically significantly in excess in either of the two largest studies of combined cohorts of occupationally exposed workers, were identified as candidate tumors for which a possible etiological role of TCDD might need investigation in future studies.
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