Spectrophotometric Determination of Niclosamide Using P-Benzoquinone
作者:
S.A. Abdel Fattah,
期刊:
Spectroscopy Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 5
页码: 795-804
ISSN:0038-7010
年代: 1997
DOI:10.1080/00387019708001628
出版商: Taylor & Francis Group
关键词: Niclosamide Determination;P-benzoquinone;spectrophotometry
数据来源: Taylor
摘要:
A simple spectrophotometric method for the determination of niclosamide in pure and dosage forms has been developed. The proposed method is based on the reduction of the nitro group in niclosamide to the amino group by heating in a water bath a mixture of niclosamide solution in 95% ethanol, zinc powder and dilute hydrochloric acid for 15 minutes. The cold and clear filtrate reacts with p-benzoguinone, where a compound of pink colour is obtained which absorbs maximally at 506 nm.
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