Interleukin-3-Specific Modification of Cell Membrane“Fluidity”of Haemopoietic Cells
作者:
LaskayGábor,
DaleRobert E.,
JelínekJaroslav,
SpooncerElaine,
DexterT. Michael,
期刊:
Growth Factors
(Taylor Available online 1988)
卷期:
Volume 1,
issue 1
页码: 67-73
ISSN:0897-7194
年代: 1988
DOI:10.3109/08977198809000248
出版商: Taylor&Francis
关键词: interleukin-3;haemopoiesis;leukaemia;membrane order/dynamics/fluidity;DPH (diphenylhexatriene);fluorescence depolarization/anisotropy
数据来源: Taylor
摘要:
AbstractThe work reported here clearly demonstrates that a specific growth factor, interleukin-3 (IL-3), which acts on multipotent haemopoietic stem cells as well as on committed myeloid progenitor cells of different lineages (Schrader, 1988; Whetton and Dexter, 1986), specifically induces a modification of the physical state (“fluidity”) of the cell membranes of two IL-3–responsive and apparently normal haemopoietic cell lines. Furthermore, in a derived IL-3 independent myeloid leukaemic cell line, no such physical response to IL-3 binding was observed. The rapidity of the“normal”response suggests further that it may be associated with, or even constitute per se a critical early effect elicited by IL-3 in sensitive cells, the necessity for which is abrogated in the malignant derivative.
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