Serum response of all-trans and 9-cis isomers of beta-carotene in humans.
作者:
JohnsonE J,
KrinskyN I,
RussellR M,
期刊:
Journal of the American College of Nutrition
(Taylor Available online 1996)
卷期:
Volume 15,
issue 6
页码: 620-624
ISSN:0731-5724
年代: 1996
DOI:10.1080/07315724.1996.10718639
出版商: Routledge
数据来源: Taylor
摘要:
Little work has been performed on the serum response of various carotene isomers. The present study was carried out to examine the serum response of all-trans and 9-cis isomers of beta-carotene (BC) using frequent blood sample collections at early time points.Serum responses of all-trans BC and a mixture of BC isomers containing 80% 9-cis BC were studied in 15 men by measuring the serum concentrations of BC at 1, 3, 5, 7, 9, 12, and 24 hours after a single large oral dose of all-trans BC or 9-cis BC.The serum response to an oral dose of all-trans BC (120 mg) significantly increased from baseline at 24 hr (p<0.004). After an oral dose of a mixture of BC isomers (120 mg, 80% 9-cis BC), the peak concentration of 9-cis BC was significantly greater that baseline values (p<0.016).Increases in serum all-trans BC levels, in part, may be due to greater intestinal absorption, whereas the inability to measure a significant increase in the concentration of 9-cis BC may indicate poor absorption, isomerization to all-trans BC, or a very rapid tissue uptake.
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