Effects of Intra-abdominal Hypertension on Hepatic Energy Metabolism in a Rabbit Model
作者:
Toshio,
Nakatani Yoshimasa,
Sakamoto Ichiro,
Kaneko Hirofumi,
Ando Kunio,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1998)
卷期:
Volume 44,
issue 3
页码: 446-453
ISSN:0022-5282
年代: 1998
出版商: OVID
数据来源: OVID
摘要:
BackgroundIntra-abdominal hypertension is known to decrease hepatic blood flow, but its effect on hepatic energy level has not described.MethodsFifty-three rabbits were mechanically ventilated and divided into five groups. Intra-abdominal hypertension was induced by saline infusion and maintained for 30 minutes. Hepatic sinusoidal functional blood flow was evaluated by means of indocyanine green disappearance rate (ICG-K), hepatic mitochondrial redox status was evaluated by arterial ketone body ratio, and tissue energy level was evaluated by energy charge (EC).ResultsAt an intra-abdominal pressure of 20 mm Hg, ICG-K was significantly decreased, with no decrease in EC. At 30 mm Hg, hypoxemia developed and the ICG-K decreased further, with significant decreases observed in arterial ketone body ratio and EC. The latter were not increased by administration of oxygen.ConclusionAt an intra-abdominal pressure of 20 mm Hg, a slight decrease in sinusoidal flow did not affect hepatic energy level. At 30 mm Hg, a reduced hepatic mitochondrial redox status and a decreased energy level were attributed to a decrease in sinusoidal flow in this animal model.
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