Exacerbation of Dideoxycytidine‐Induced Neuropathy with Dideoxyinosine
作者:
Susan LeLacheur,
Gary Simon,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1991)
卷期:
Volume 4,
issue 5
页码: 538-539
ISSN:0894-9255
年代: 1991
出版商: OVID
关键词: Dideoxycytidine;Dideoxyinosine;Human immunodeficiency virus;Zidovudine;Peripheral neuropathy
数据来源: OVID
摘要:
Dideoxycytidine (ddC) and dideoxyinosine (ddI) are nucleoside derivatives that exhibit antiretroviral activity against the human immunodeficiency virus (HIV). Both of these agents are under active investigation as potential therapies for patients with HIV infection. In addition, both drugs may be obtained for HIV-infected individuals who cannot tolerate zidovudine. A major focus of the research effort involving these agents has been to define their toxicities. Both agents may cause peripheral neuropathy. We wish to report a patient who developed severe neuropathy following the administration of ddI that was given shortly after the patient was removed from a clinical trial of ddC. The rapid development of toxicity indicates that this side effect is additive or synergistic for these agents.
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