Physiologic and rheologic effects of the antisickling agent ethacrynic acid and its N‐butylated derivative on normal and sickle erythrocytes
作者:
Eugene P. Orringer,
David S. Blythe,
James A. Whitney,
Scott Brockenbrough,
Donald J. Abraham,
期刊:
American Journal of Hematology
(WILEY Available online 1992)
卷期:
Volume 39,
issue 1
页码: 39-44
ISSN:0361-8609
年代: 1992
DOI:10.1002/ajh.2830390109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: hemoglobin S;red blood cells;loop diuretic
数据来源: WILEY
摘要:
AbstractEthacrynic acid, a loop diuretic, has been shown to inhibit hemoglobin S polymerization. Until now, however, most studies were performed using purified solutions of hemoglobin S. The experiments reported here were designed to examine the effects of ethacrynic acid and its n‐butryic acid derivative on the rheological and physiological properties of intact red blood cells. Using net and unidirectional flux measurements, both agents were shown to cause ion and water loss from normal and sickle erythrocytes. Since cell shrinkage adversely influences red cell rheology, it is unlikely that this class of compounds, despite its ability to inhibit hemoglobin S polymerization, will prove useful in the treatment of sickle cell diseas
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