Vibro-acoustic energy travels through hose walls as longitudinal waves and flexural waves, apart from the sound waves through the fluid medium inside. Longitudinal waves in the hose wall are coupled to the sound waves inside by means of the hose-wall Poisson’s ratio. Both in turn get coupled to bending or flexural waves because of the energy transfer or interaction at the bends. For any of these three types of waves incident on one end of a hose, waves of all the three types may be transmitted on the other end because of their dynamical coupling with one another. Therefore, in the present paper, expressions have been derived for the 3×3 transmission loss matrix for a two-dimensional or planar piping system in terms of elements of the overall 8×8 transfer matrix of the system. These expressions have then been used in a comprehensive computer program to evaluate the vibro-acoustic performance of hoses, with particular application to the automotive climate control systems with gaseous as well as liquid media. Finally, parametric studies have been made that have led to some general design guidelines.