Herpes Simplex Types 1 and 2: Latency in the Genital Tract of Guinea Pigs
作者:
Marie L. Landry,
Cathy Bull,
期刊:
Intervirology
(Karger Available online 1992)
卷期:
Volume 33,
issue 4
页码: 204-210
ISSN:0300-5526
年代: 1992
DOI:10.1159/000150252
出版商: S. Karger AG
关键词: Herpex simplex virus;latency;Genital herpes
数据来源: Karger
摘要:
Guinea pigs were infected with herpes simplex virus (HSV) intravaginally and then sacrificed during latent infection. Virus was recovered from the ganglia, spinal cord and genital tissues by co-cultivation after 1-6 weeks in culture. The virus could not be recovered from the genital tract during the first week of co-cultivation, nor from homogenized genital tissue. Cultivation of genital tissues with acyclovir did not reduce the recovery of HSV. Thus, HSV appeared to establish a truly latent infection in the genital tract and not a persistent infection as previously described.
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