AbstractTwenty‐seven patients with measurable with measurable liver metastases from colorectal carcinoma were entered on a protocol of intermittent hepaticartery infusion (HAI) of 5‐fluorouracil (5‐FU) followed by consolidation with hepatic irradiation. Five partial responses were observed in 23 evaluable patients. Median duration of response was 3.5 months. A response was evident after chemotherapy alone in four of five responders. Hepatic irradiation converted one patient with stable disease after chemotherapy to a partial responder. Median survival for all patients was 9.0 months (range 1.5–34.0). Combined modality treatment with HAI of 5‐FU followed hepatic irradiation was well tolerated but did not appear to be sy