Indirect Determination of some Analgesic-Inflammatory Drugs by AAS
作者:
Güzin Alpdoğan,
Sidika Sungur,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 14
页码: 2799-2808
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908543007
出版商: Taylor & Francis Group
关键词: Mefenamic acid;flufenamic acid;diclofenac sodium;atomic absorption spectrophotometry
数据来源: Taylor
摘要:
An Indirect AAS method has been developed for the determination of analgesic-inflammatory drugs, mefenamic acid, flufenamic acid and diclofenac sodium. The method depends on the complexation with copper (II) ammine sulphate. The complex was extracted into chloroform and the concentrations of substances were determined indirectly by AAS measurement of copper, after re-extraction into 0.3 N nitric acid solution. The developed method was applied to the assay of the drug substances in commercial tablet formulations. The results were statistically compared with those obtained by HPLC method by t- and F-tests at 95% confidence level. Calculated t and F values were both lower than the table values.
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