AbstractTwenty–six children with a symmetric papular or papulovesicular acrolocated eruption were studied to evaluate a possible link with viral infection. A history of a recent immunization was present in four patients, two of whom had a polio vaccine virus isolated from their stool samples. There was serologic evidence of a recent Epstein–Barr virus infection in one patient, adenovirus infection in another, a concurrent Epstein–Barr virus and adenovirus Infection in a third, and cytomegalovirus infection in a fourth. Viral cultures were positive in two patients for adenovirus and in two others for rotavirus. Although some of the virologlc findings could have been coincidentai, this study confirms that multiple virai infections can be reiated to most papular and papulovesicular acrolocated eruptions of chiidhood. Virologic investigations in the eariier phases of the eruption are recommended to identify the etiologic factors of these le