In the year that has elapsed since the previous review of this subject, there is some evidence that the prevalence pattern of deep soft tissue infections may be changing. Perhaps not surprisingly, a prominent predisposing factor associated with the occurrence of deep soft tissue infections is the presence of some form of host immunoalteration. Thus, advanced age, administration of exogenous immunosuppressive medication for transplantation and inflammatory diseases, diabetes mellitus, and infection with the human immunodeficiency virus are increasingly common risk factors identified in reports of patients who develop deep soft tissue infections.