Stress-responsive signal transduction mechanisms in glomerular cells
作者:
Alistair Ingram,
James Scholey,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 2000)
卷期:
Volume 9,
issue 1
页码: 49-55
ISSN:1062-4821
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
Mechanical stresses appear to play a key role in the progression of glomerular diseases that are characterized by increased transcapillary hydraulic pressure. Glomerular mesangial cells proliferate and produce extracellular matrix proteinsin vivoin such diseases. Mesangial cell responses to pulsatile mechanical stimuli have been studied extensivelyin vitroduring the past few years. Mechanical signals are sensed at the cell membrane and propagated through the cytoplasm, and result in the activation of transcription factors that elicit production of prosclerotic cytokines and matrix proteins, and cell proliferation. Endothelial cells are exposed to shear and pulsatile stress and show some similar responses in other vascular beds.
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