Arf 193nm excimer laser corneal surgery and photo-oxidative stress in aqueous humor and lens of rabbit: one-month follow-up
作者:
CostagliolaCiro,
BalestrieriPaola,
FiorettiFelice,
FrunzioStefano,
RinaldiMichele,
ScibelliGennaro,
期刊:
Current Eye Research
(Taylor Available online 1996)
卷期:
Volume 15,
issue 4
页码: 355-361
ISSN:0271-3683
年代: 1996
DOI:10.3109/02713689608995825
出版商: Taylor&Francis
关键词: photorefractive keratectomy;excimer laser;cataract;cataractogenesis;UV radiation;rabbit
数据来源: Taylor
摘要:
Twenty male albino rabbits were studied. Four animals served as controls; the remaining 16 animals represented the treated group. All the treated animals were exposed to the same amount of energy delivered by the excimer laser (pulse rate: 20 Hz, fluence 250mJ/cm2; number of pulses: 6032; cumulative UV dose 1508 J/cm2) and were divided into eight groups of 2 animals each (four eyes). Samples of aqueous humor and lens were obtained at the following intervals: 5, 10, 20 and 40 min and 1,2,3 and 4 weeks after photorefractive keratectomy (PRK). The levels of reduced and oxidized glutathione, hydrogen peroxide, ascorbic acid and malondialdehyde were determined.Aqueous humor analyses, twenty min after PRK, showed no significant differences with pre-treatment values, while the observed variations in lens were constantly present over the entire follow-up period (one month).These findings suggest that the biochemical lens alterations induced by PRK may represent the earliest events relevant to cataractogenesis in the rabbit.
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