Electrophysiological actions of luteinizing hormone‐realeasing hormone: Intracellular studies in the rat hippocampal slice preparation
作者:
Michael Wong,
Misty J. Eaton,
Robert L. Moss,
期刊:
Synapse
(WILEY Available online 1990)
卷期:
Volume 5,
issue 1
页码: 65-70
ISSN:0887-4476
年代: 1990
DOI:10.1002/syn.890050106
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Neuropeptide;Ca1 neurons;Afterhyperpolarization;Accommodation
数据来源: WILEY
摘要:
AbstractThe electrophysilogical effects of luteinizing hormone‐releasing hormone (LHRH) on CA1 pyramidal cells were investigated utilizing intracellular recodings from the in vitro rat hippocampal slce preparation. Bath application of LHRH (10‐7‐10‐12M) resulted in several changes in the electrophysiological properties of CA1 neurons. LHRH induced a long‐lasting depolarization associated with increased input resitance, and decrease in the afterhyperpolarization associated with increased input resistance, ad decrease in the afterhyperpolarization (AHP) following a train of action potentials, and a reduction in accommodation of repetitive cell discharge. These effects were blocked by the synthetic LHRH antagonist [Ac‐δ‐Pro1, pCl‐D‐Phe2, D‐Trp3,6]‐LHRH. These findings provide electrophysiological evidence for the role of LHRH as a neurotransmitter/neuromodula
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