Protective Effect of Zinc-Induced Metallothionein Synthesis on Gentamicin Nephrotoxicity in Rats
作者:
LingChao,
HaiXue,
ZhongWan,
ChenWen,
期刊:
Renal Failure
(Taylor Available online 1991)
卷期:
Volume 13,
issue 4
页码: 227-232
ISSN:0886-022X
年代: 1991
DOI:10.3109/08860229109022158
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Wistar rats were used to study the protective effect of zinc-induced metallothionein (MT) synthesis on gentamicin nephrotoxicity. We found that s.c. pre-injection of ZnSC4(Zn 10 mg/kg/day) for 5 days could ameliorate proximal tubular necrosis and acute renal failure caused by an 8-day s.c. injection of gentamicin (100 mg/kg/day), while preinjection of saline instead of zinc or zinc and gentamicin together could not. In the zinc-pretreated rats (n = 6), renal cortical metallothionein level was significantly higher than that of normal (n = 8, p<0.001) and the saline controls (n = 6, p<0.001). Since MT is a scavenger of hydroxyl radical, it is proposed that hydroxyl radical plays a role in the pathogenesis of gentamicin nephrotoxicity and that preinjection of zinc could ameliorate gentamicin nephrotoxicity via the induction of renal cortical MT synthesis.
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