Drug-induced changes in repolarization of the heart can be reflected in a prolonged QT interval, an indication of increased risk of serious ventricular arrhythmias, particularly torsade de pointes, and sudden death. Drugs responsible include:Class IA and Class III antiarrhythmic drugs, such as quinidine and sotalol; some psychiatric drugs, such as pimozide and thioridazine; some non-sedating antihistamines, such as astemizole and terfenadine; some antimicrobial drugs, such as erythromycin, pentamidine, quinine and halofantrine, and some other drugs, including terodiline.