Diagnostic value of two rapid and individual D‐dimer assays in patients with clinically suspected pulmonary embolismcomparison with microplate enzyme‐linked immunosorbent assay
作者:
G. Meyer,
A. Fischer,
M. Collignon,
A. Benazzouz,
F. Monge,
H. Sors,
E. de Raucourt,
期刊:
Blood Coagulation and Fibrinolysis
(OVID Available online 1998)
卷期:
Volume 9,
issue 7
页码: 603-608
ISSN:0957-5235
年代: 1998
出版商: OVID
关键词: pulmonary embolism;diagnosis;D-dimer
数据来源: OVID
摘要:
A semiquantitative enzyme-linked immunosorbent assay (ELISA) test (Instant IA D-dimer) and a new quantitative rapid and individual test (STA-Liatest DDi) were compared with the reference microplate ELISA (Asserachrom D-Di) for D-dimer testing in 142 patients clinically suspected of pulmonary embolism, on the basis of clinical symptoms and signs, electrocardiogram, blood gases and chest X-Ray abnormalities. The cut-off value for the quantitative tests was 500 ng/ml and Instant IA was interpreted by three readers. Pulmonary embolism was confirmed by lung scan or angiography in 60 patients (42%). The sensitivities of ELISA and STA-Liatest DDi were 92% [95% confidence interval (CI) 82–97%] and 93% (95% CI 84–98%), respectively. The three readings of Instant IA D-dimer disagreed in 27 (19%) of the patients and sensitivity varied from 83 to 93% according to the readers. In the 115 patients with concordant readings, sensitivity was 92% (95% CI 82–98%). These results suggest that STA Liatest DDi may be used instead of microplate ELISA for the exclusion of pulmonary embolism, whereas the use of Instant IA D-dimer for this purpose is limited by the number of discordant results.
点击下载:
PDF
(462KB)
返 回