Genetic and ethanol‐related differences in maternal behavior and offspring viability in mice
作者:
Karen M. Swanberg,
James R. Wilson,
期刊:
Developmental Psychobiology
(WILEY Available online 1979)
卷期:
Volume 12,
issue 1
页码: 61-66
ISSN:0012-1630
年代: 1979
DOI:10.1002/dev.420120107
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractPrimiparous female mice of 2 lines genetically selected for different narcotic responses to ethanol were administered 10% (v/v) ethanol in their drinking water during Days 2–14 of lactation. Ethanol treatment resulted in a marked decrease in growth and viability of pups in both lines. Fewer offspring of the ethanol‐sensitive line survived to weaning, apparently because of the failure of a large number of dams to exhibit maternal care. The combination of ethanol treatment and an additional environmental stressor (mouse hepatic virus) had a devastating effect on maternal behavior and offspring survival in the ethanol‐sensitive line, but far less effect on the ethanol‐insensitive mice. Thus, ethanol‐sensitive animals appear to be more susceptible to a variety of stressors, includin
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