Lipid Metabolism, Atherogenesis, and Haemostasis in Eskimos: the Role of the Prostaglandin-3 Family
作者:
J. Dyerberg,
H.O. Bang,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1979)
卷期:
Volume 8,
issue 3-5
页码: 227-233
ISSN:1424-8832
年代: 1979
DOI:10.1159/000214314
出版商: S. Karger AG
关键词: Bleeding time;Eskimos;Fatty acids;Platelet aggregation;Prostaglandin-3 family
数据来源: Karger
摘要:
In Eskimos coronary heart disease is a rarity. This can partly be explained by their favorable plasma lipid levels. An additional factor seems, however, to be that in Eskimo food polyunsaturated fatty acids of the ω-3 series replace those of the ω-6 series. C20:5, ω-3 can be converted by the vessel wall to an antiaggregatory substance, whereas it has no proaggregatory effect on platelets. Consistent with these findings Eskimos were found to have a nearly 2-fold longer bleeding time than Danes. Platelet aggregability, too, was merkedly depressed when exposing platelets from Eskimos to ADP and collag
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