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Metabolism and disposition ofortho‐benzyl‐para‐chlorophenol in male rats

 

作者: W. P. Ridley,   M. R. Sewall,   M. W. Dietrich,  

 

期刊: Journal of Toxicology and Environmental Health  (Taylor Available online 1986)
卷期: Volume 18, issue 2  

页码: 267-283

 

ISSN:0098-4108

 

年代: 1986

 

DOI:10.1080/15287398609530867

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

The metabolism and disposition ofortho‐benzyl‐para‐chlorophenol (BCP) has been investigated in the male rat following an oral dose of 69 mg/kg or 206 mg/kg. BCP was rapidly eliminated at both dose levels with 45–49% of the dose appearing in the urine and 44–49% in the feces during the 5‐d period after dosing. After 5 d only 0.28–0.3% of the dose remained in the body, with almost half this value accounted for in the liver and kidney. The dynamics for the overall elimination of radioactivity from the body was biphasic at both dose levels. The initial rapid a phase had a well defined half‐life of 8–9 h, and the slower β phase had an estimated half‐life of approximately 52–140 h.

 

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