Metabolism and disposition ofortho‐benzyl‐para‐chlorophenol in male rats
作者:
W. P. Ridley,
M. R. Sewall,
M. W. Dietrich,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1986)
卷期:
Volume 18,
issue 2
页码: 267-283
ISSN:0098-4108
年代: 1986
DOI:10.1080/15287398609530867
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The metabolism and disposition ofortho‐benzyl‐para‐chlorophenol (BCP) has been investigated in the male rat following an oral dose of 69 mg/kg or 206 mg/kg. BCP was rapidly eliminated at both dose levels with 45–49% of the dose appearing in the urine and 44–49% in the feces during the 5‐d period after dosing. After 5 d only 0.28–0.3% of the dose remained in the body, with almost half this value accounted for in the liver and kidney. The dynamics for the overall elimination of radioactivity from the body was biphasic at both dose levels. The initial rapid a phase had a well defined half‐life of 8–9 h, and the slower β phase had an estimated half‐life of approximately 52–140 h.
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