AbstractThe PCS is an automated centrifugal system designed for rapid collection of platelet poor plasma (PPP) for source or fresh frozen uses, or platelet concentrate and PPP. The microprocessor‐controlled system increases plasma collection efficiency through improved plasma yields, increased donor safety, and operation of multiple machines per operator.600 ml of plasma can be collected in an average of 35 minutes per procedure with greater than 50,000 collections by U.S. commercial organizations. PCS plasma yields 10% greater Factor VIII recovery through fractionation when compared to manually‐collected plasma based upon multiple studies throughout the world. Collection of PRP is an efficient, reliable, safe, and cost‐effective method for processing plasma and the only system available for combined platelet and plasma procur