Mechanism of Action of Somatostatin
作者:
M.J. Toro,
L. Birnbaumer,
M.C. Redon,
E. Montoya,
期刊:
Hormone Research in Paediatrics
(Karger Available online 1988)
卷期:
Volume 29,
issue 2-3
页码: 59-64
ISSN:1663-2818
年代: 1988
DOI:10.1159/000180969
出版商: S. Karger AG
关键词: Somatostatin;Internalization;Membrane action;Cytosol
数据来源: Karger
摘要:
The chain of events leading to the manifestation of the biological action of somatostatin are described. Internalization is mediated by cytoskeletal proteins in the presence of calmodulin. Transduction of the somatostatin message at the membrane level takes place through inhibition of cyclic AMP accumulation and blockade of cytosol calcium increases. The influence of central and peripheral factors upon these processes is discussed and the importance of the Ni/Ns components is stressed. Thus, somatostatin also suppresses phosphoinositide turnover and stimulates soluble phosphodiesterase, thus reinforcing its negative effect on cyclase generation.
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