Acute Renal Failure and Severe Hypertension in Children with Renal Thrombotic Microangiopathy
作者:
U.N. Bhuyan,
A. Bagga,
R.N. Srivastava,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 66,
issue 3
页码: 302-306
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187827
出版商: S. Karger AG
关键词: Acute renal failure;Severe hypertension;Thrombotic microangiopathy;Hemolytic uremic syndrome
数据来源: Karger
摘要:
We observed 12 boys and 1 girl, 5-15 years old, presenting with acute renal failure (ARF) and severe hypertension. They constituted 4.9% of all patients with ARF. There was no preceding diarrheal or respiratory prodrome. Clinical and laboratory findings were indicative of hemolytic uremic syndrome (HUS) in 4, but obscure in 9 others. Renal biopsies revealed variably severe occlusive thrombotic microangiopathy (TMA) affecting predominantly interlobular arteries in 8 and both arteries and glomeruli in 5 cases. Glomerular crescents and cortical necrosis were not seen. Following supportive therapy, 8 progressed to or died of uremia; 2 showed persistent proteinuria, 1 moderate hypertension and 2 complete recovery. Our observations indicate that renal TMA without a prodromal illness and typical features of HUS may present with ARF, proteinuria and severe hypertension, and is associated with high mortality.
点击下载:
PDF
(843KB)
返 回