Infusion of GDNF into the cerebral spinal fluid through two different routeseffects on body weight and corticospinal neuron survival
作者:
Klaus Giehl,
Claudia Schacht,
Qiao Yan,
Pedro Mestres,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2809-2813
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Adult;Axotomy;CSF;CSN;Rat
数据来源: OVID
摘要:
SURVIVAL of axotomized adult rat corticospinal neurons (CSN) is supported by glial cell line-derived neurotrophic factor (GDNF). We have evaluated the trophic effects of intrathecally applied GDNF on CSN survival and rat body weight. Body weight reduction is the major side effect of intracerebral neurotrophic factor treatment. GDNF was tested at total doses of 30, 100 and 300 mg over 7 days after axotomy via different application routes: intracerebroventricularly (i.c.v.) and cisternally (cis). Animals injected i.c.v. displayed severe body weight reduction at all doses tested but CSN rescueonly at the highest dose. In contrast, cis-infusion of GDNF promoted CSN survival at all doses and only the highest dose reduced the body weight. These results show that intracisternal, but not i.c.v., GDNF infusion at low doses canpromote CSN survival without negatively affecting rat body weight. This finding may have implications for the clinic use of GDNF.
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