Mls: A Link Between Immunology and Retrovirology
作者:
AchaHans,
HeldWerner,
ScarpellinoLeonardo,
ShakhovAlexander N.,
期刊:
International Reviews of Immunology
(Taylor Available online 1992)
卷期:
Volume 8,
issue 4
页码: 327-336
ISSN:0883-0185
年代: 1992
DOI:10.3109/08830189209053516
出版商: Taylor&Francis
关键词: Mls;minor lymphocyte stimulating;MMTV;mouse mammary tumor virus;T cell receptor;MHC;open reading frame;superantigen
数据来源: Taylor
摘要:
The nature of the mysterious minor lymphocyte stimulating (Mls) antigens has recently been clarified. These molecules which were key elements for our current understanding of immune tolerance, have a strong influence on the mouse immune system and are encoded by the open reading frame (orf) of endogenous and exogenous mouse mammary tumor viruses (MMTV's). The knowledge that these antigens are encoded by cancerogenic retroviruses opens an interdisciplinary approach for understanding the mechanisms of immune responses and immune tolerance, retroviral carcinogenesis, and retroviral strategies for infection.
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