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Spectrophotometric Assay of Certain Aminoglycosoide Antibiotic Using Chloranil

 

作者: M. Rizk,   P. Younis,  

 

期刊: Analytical Letters  （Taylor Available online 1984）
卷期: Volume 17, issue 16  

页码: 1803-1809

 

ISSN:0003-2719

 

年代: 1984

 

DOI:10.1080/00032718408077183

 

出版商: Taylor & Francis Group

 

关键词: Aminoglycosoide antibiotics-determination;Chloranil, Spectrophotometric assay;charge-transfer complexation;Kanamycin, Amikacin;Neomycin;tobramycin-dosage forms.

 

数据来源: Taylor

 

摘要:

Chloranil (2,3,5,6-teterachloro-p-benzoquinone) reacts with certain aminoglycosoide antibiotics in borate buffer at pH 9.0 to give charge-transfer complexes. The complexes possese an absorption maxmum at about 350 nm with molar absorptivities of 3.78 × 105, 4.69 × 105, 5.0 × 105and 7.08 × 105for kanamycin, neomycin B, amikacin and tobramycin reepectively, These high intensity of the chargetransfor band and confirmity to beer's law enabled assay of these antibiotics with appreciable sensitivity and good precision.

 

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