Caspase inhibitors prevent cisplatin‐induced apoptosis of auditory sensory cells
作者:
Wei Liu,
Hinrich Staecker,
Howard Stupak,
Brigitte Malgrange,
Philippe Lefebvre,
Thomas Van De Water,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 11
页码: 2609-2614
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Apoptosis;Auditory sensory cells;Caspases;Caspase inhibitors;Cisplatin damage;Protection
数据来源: OVID
摘要:
IN VITROstudies tested the efficacy of three caspase inhibitors, Ac-VAD-cmk (caspase-1 inhibitor), z-DEVD-fmk (caspase −3 inhibitor) and B-D-fmk (BOCDFK, a general inhibitor), for protecting auditory sensory cells from cisplatin-damage induced loss. Treatment of 3-day-old rat organ of Corti explants with these caspase inhibitors protected > 80% of the auditory hair cells from cisplatin-damage initiated apoptosis. Dissociated cell cultures of 3-day-old rat spinal ganglia treated with any of these three caspase inhibitors in addition to exogenous neurotrophin have highly significant increases in neuronal survival following cisplatin exposure. These results indicate that loss of auditory sensory cells as a result of cisplatin-induced damage involves apoptosis and that blocking of this cell death pathway at the caspase level effectively rescues both hair cells and neurons.
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