A Human Anti-Cardiolipin Autoantibody is Encoded by Developmentally restricted Heavy and Light Chain Variable Region Genes
作者:
SiminovitchKatherine a.,
MisenerVirginia,
KwongPak C.,
MingPei,
LaskinCarl A.,
CairnsEwa,
BellDavid,
RubinLaurence A.,
ChenPojen P.,
期刊:
Autoimmunity
(Taylor Available online 1990)
卷期:
Volume 8,
issue 2
页码: 97-105
ISSN:0891-6934
年代: 1990
DOI:10.3109/08916939008995727
出版商: Taylor&Francis
关键词: Autoantibody;anti-cardiolipin antibody;natural autoimmunity;immune repertoire;repertoire restriction;variable gene usage
数据来源: Taylor
摘要:
Based on recent structural analyses of monoclonal autoantibodies, it appears that a number of these antibodies express germ-line immunoglobulin variable region (V) genes with little or no somatic mutation. In addition, our group and others have noted the identity or near identity of some autoantibody-associated V genes to V genes apparently expressed preferentially in the fetal pre-B cell repertoire. To extend these data, we now report that the heavy and light chain V genes of an anti-cardiolipin antibody derived from a healthy individual display 99% nucleotide sequence homology with V genes expressed in early B cell ontogeny. Sequence comparisons indicate the likely use of fetal-restricted V genes by this autoantibody. Taken together with other data on autoantibody V gene usage, these findings provide further evidence for overlap between the autoantibody-associated and early ontogeny expressed V gene repertoires and suggest that natural autoreactivity may be instrumental in the development and maintenance of the normal immune repertoire.
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