The expression of HLA-antigens in the human anterior uvea
作者:
BakkerMargreet,
KijlstraAize,
期刊:
Current Eye Research
(Taylor Available online 1985)
卷期:
Volume 4,
issue 5
页码: 599-604
ISSN:0271-3683
年代: 1985
DOI:10.3109/02713688508999991
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The expression of MHC Class I and Class II antigens was investigated in the human uvea using monoclonal antibodies in an indirect immuno fluorescence technique. The anterior border layer of the iris, the non-pigmented and pigmen ted epithelium of the ciliary body, the external basement membrane of the ciliary body and the vascular endothelium in the uvea showed a positive staining for Class I antigens. The endothelium lining the bloodvessels in the uvea expressed the highest density of Class I antigens. Class II antigens were found only on single cells spread throughout the entire uvea. These cells did not seem to relate to any anatomical entity. No staining for Class II antigens was detected in the uveal blood vessel endothelium. The expression of HLA-antigens in the uvea may provide insight in the pathogenesis of certain HLA associated uveitis entities.
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