AbstractMagnetic resonance imaging has recently been developed as a tool to image brain function based on regional changes in blood oxygenation. In this article, we examine the methodologic considerations for functional brain mapping using the spiral k‐space acquisition technique. Gradient design and image reconstruction methods as well as considerations for the selection of imaging parameters are presented. Several sources of image artifacts, along with artifact compensation strategies, are examined. Functional maps of activation in primary motor cortex are usd to demonstrate the effect of image parameter selection and of artifact compensation procedures. These results demonstrate that the spiral k‐space acquisition technique is a rapid, flexible, and robust method for imaging brain activ