Interaction Between Ionophores and Biomimetic Membranes
作者:
C. Betrencourt,
A. Hochapfel,
H. Hasmonay,
P. Peretti,
M. Ollivon,
C. Grabielle-madelmont,
期刊:
Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals
(Taylor Available online 1995)
卷期:
Volume 262,
issue 1
页码: 179-190
ISSN:1058-725X
年代: 1995
DOI:10.1080/10587259508033524
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Insertion properties of Lasalocid and Monensin as sodium salts (LAS-Na, MON-Na) in model membranes of dipalmitoylphosphatidylcholine (DPPC) have been studied in two biomimetic buffered systems: monolayers (Langmuir Film Balance) and multilamellar bilayers (Differential Scanning Calorimetry). Effects varying with the concentration and with the surface pressure have been observed within the experimental range of molar ratios r = antibiotic/lipid from 0.005 to 0.1. The area occupied by each antibiotic molecule and the relative molecular area increase at a given pressure, are different for the two molecules. The calorimetric measurements result in concentration dependent modifications of the characteristics of the gel-liquid crystal phase transition in the case of LAS-Na. No such modifications are observed in the case of MON-Na.
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