BINDING OF ANTHRACENE TO CELLULAR MACROMOLECULES IN THE PRESENCE OF LIGHT
作者:
Birandra Kumar Sinha,
Colin F. Chignell,
期刊:
Photochemistry and Photobiology
(WILEY Available online 1983)
卷期:
Volume 37,
issue 1
页码: 33-37
ISSN:0031-8655
年代: 1983
DOI:10.1111/j.1751-1097.1983.tb04430.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractUltraviolet radiation (δ>295 nm) induced covalent binding of anthracene to DNA which increased with time and was not affected by oxygen. Irradiation in the presence of anthracene induced nicking of Col E, circular DNA and decreased the thermal denaturation temperature of calf thymus DNA. These effects were oxygen dependent, and were decreased by GMP. Irradiation of anthracene and human serum albumin resulted in covalent binding of the hydrocarbon to the protein accompanied by crosslinking of the protein. Protein crosslinking decreased under anaerobic conditions. Irradiation of anthracene bound to liposomes induced lipid peroxidation which was not affected by superoxide dismutase or catalase
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