Matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry of DNA–Pt(II) complexes
作者:
J. Guittard,
C. Pacifico,
J. C. Blais,
G. Bolbach,
J. C. Chottard,
A. Spassky,
期刊:
Rapid Communications in Mass Spectrometry
(WILEY Available online 1995)
卷期:
Volume 9,
issue 1
页码: 33-36
ISSN:0951-4198
年代: 1995
DOI:10.1002/rcm.1290090109
出版商: Heyden&Son Limited
数据来源: WILEY
摘要:
AbstractMatrix‐assisted laser desorption ionization (MALDI) time‐of‐flight mass spectrometry has been used to characterize the reaction products of the 18‐mer deoxyribonucleotide d(AACGGTTAACCGTTAATT) with [Pt(NH3)3(H2O)]2+andcis‐[Pt(NH3)2(H2O)2]2+. Characteristic peaks corresponding to different monofunctional adducts {18‐mer+n[Pt(NH3)3]} (n=1, 2, 3 and 4) have been observed with the triamino–monoaqua complex. With the diamino‐diaquacis‐Pt complex, formation of a chelate {18‐mer+[Pt(NH3)2]} involving two adjacent guanines has been demonstrated. A good correlation between MALDI and polyacrylamide gel electrophoresis
点击下载:
PDF
(364KB)
返 回