Ageing is certainly one of the most important current problems; in fact, according to statistics, the old population of the world is continuously increasing. Depression represents the most frequent psychiatric problem in the aged, if it is considered that almost 25% of the old population are affected by it. An early diagnosis and a proper treatment are crucial problems. Because of the numerous side effects of tricyclic antidepressants, today we are able to use some third-generation antidepressants which show unquestionable advantages in the therapy of depression in the elderly. Trazodone is one of these antidepressive drugs and represents a real leader among the antidepressants. Our care is to work so that these recent and efficient drugs may be correctly and properly utilized by physicians prepared to face this often totally new task.