Determination of Certain Antihistamines Through Ternary Complex Formation
作者:
Magda Ayad,
Hana Saleh,
Magda El-Mammli,
Mohamed El-Bolkiny,
Magda El-Henawee,
期刊:
Analytical Letters
(Taylor Available online 1993)
卷期:
Volume 26,
issue 5
页码: 913-923
ISSN:0003-2719
年代: 1993
DOI:10.1080/00032719308019874
出版商: Taylor & Francis Group
关键词: Terfenadine;chlophenoxamine hydrochloride;spectrophotometry;atomic absorption spectroscopy
数据来源: Taylor
摘要:
Antihistamines, namely terfenadine and chlorphenoxamine hydrochloride, react with cobalt and toxiocyanate ions to give ternary complexes. These complexes are readily extractable in benzene to give a blue colour with maximum absorption at 625nm. which can be used for Quantitative spectrophotometric analysis. The mean recoveries for authentic samples of terfenadine and chlorphenoxamine hydrochloride were 99.9 ± 0.3 S.E. and 99.9 ± 0.3 respectively (P = 0.05). Alternatively, determination of cobalt content of the benzene extract via atomic absorption spectroscopy provides an indirect method for the determination of these antihistamines. The mean recoveries were 99.33 ± 0.3 and 99.19 ± 0.3 respectively. Both methods were applied to the analysis of pharmaceutical preparations, the results obtained agreed well with those obtained by official methods.
点击下载:
PDF (310KB)
返 回